Key result
Antihypertensive therapy reduced the incidence of stroke by 42% compared with placebo or less active treatment in hypertensive individuals.
Why the study?
Does antihypertensive therapy reduce the incidence of stroke in hypertensive patients?
Does antihypertensive therapy reduce the incidence of stroke in hypertensive patients?
Effect estimate: 42% reduction (95% CI 33-50)
p-value: p=<0.0001
Antihypertensive therapy provides a rapid and significant reduction in the risk of fatal and non-fatal strokes across various patient demographics and hypertension severities, though absolute benefits vary by baseline cardiovascular risk.
Supports antihypertensive use for stroke prevention in hypertension; leaves open optimal agents and targets in contemporary populations.
Antihypertensive therapy can prevent stroke. This has been shown in patients with severe as well as mild hypertension, and in young, middle-aged, and elderly hypertensive patients. However, although prevention of stroke ranks very high among the proven benefits of antihypertensive therapy, there are several aspects of this benefit that deserve discussion. These include: 1) the benefits on fatal and non-fatal strokes, respectively; 2) the possibly greater benefits resulting from a greater reduction in blood pressure than the reduction achieved in most trials; 3) the relative benefits on haemorrhagic and thrombotic strokes, respectively; 4) the effects of antihypertensive therapy in patients with a previous stroke; and 5) the efficacy of different antihypertensive drugs on stroke prevention. (Hypertens Res 1994; 17: 157-160)
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Alberto Zanchetti (1994) conducted a review in Hypertension (n=37,000). Antihypertensive therapy vs. Placebo or less active treatment was evaluated on Incidence of stroke (42% reduction, 95% CI 33-50, p=<0.0001). Antihypertensive therapy reduced the incidence of stroke by 42% compared with placebo or less active treatment in hypertensive individuals.
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