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January 1, 1994Hypertension ResearchOpen Access

The Benefit, Risks and Cost of Primary Stroke Prevention with Antihypertensive Drugs

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Why the study?

Do antihypertensive drugs reduce stroke incidence and other cardiovascular events in primary prevention?

Population

Patients receiving primary stroke prevention (hypertensive patients)

Design

Review

Authors

CBChristopher J. Bulpitt

Discussion

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Overview

Supports antihypertensives for primary stroke prevention; leaves open optimal targets and net benefit in low-risk contemporary cohorts.

Structured PICO

Do antihypertensive drugs reduce stroke incidence and other cardiovascular events in primary prevention?

P
Population
Patients receiving primary stroke prevention (hypertensive patients)
I
Intervention
Antihypertensive drugs
O
Outcome
Stroke incidencehard clinical

Antihypertensive drugs provide significant benefits in primary stroke prevention (40% reduction) and other cardiovascular outcomes, though risks and costs must be considered.

Limitations

  • Lack of good data for cost-utility analysis adjusting years of life gained by their quality

Cite This Study

Christopher J. Bulpitt (1994) studied this question.

synapsesocial.com/papers/6a70abe18031ec7bb1dc809dhttps://doi.org/10.1291/hypres.17.supplementi_s115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension1991 · 2,963 citations
  2. 2Risks and benefits in the trial of the European Working Party on High Blood Pressure in the Elderly1991 · 76 citations
  3. 3Beta-Blockers Versus Diuretics in Hypertensive Men: Main Results from the HAPPHY Trial1987 · 467 citations
  4. 4Randomised trial of treatment of hypertension in elderly patients in primary care.1986 · 729 citations
  5. 5Single-Drug Therapy for Hypertension in Men -- A Comparison of Six Antihypertensive Agents with Placebo1993 · 1,207 citations