Key result
SIRT1 expression was significantly lower in the placentas of patients with placenta accreta spectrum, while maternal and umbilical cord serum levels were not significantly different between groups.
Why the study?
Studies exploring the underlying molecular mechanisms of placenta accreta spectrum are very limited, though SIRT1 is associated with placental development.
Is SIRT1 expression altered in the placenta, maternal serum, and umbilical cord serum of patients with placenta accreta spectrum compared to controls?
Observational (n=80)
Is SIRT1 expression altered in the placenta, maternal serum, and umbilical cord serum of patients with placenta accreta spectrum compared to controls?
SIRT1 expression is reduced in the placentas of patients with placenta accreta spectrum, suggesting a potential role in its pathogenesis.
Answers are grounded in this paper and cite their sources.
Reduced placental SIRT1 in PAS is hypothesis-generating; does not support serum testing or practice change.
OBJECTIVE: Placenta accreta spectrum (PAS) is defined as the attachment of the placenta to the uterine wall in varying degrees. However, the studies have explored that the underlying molecular mechanisms of the PAS are very limited. Sirtuins 1 (SIRT1) is associated with placental development by controlling trophoblast cell invasion and remodeling of spiral arteries. We aimed to determine the expression level of SIRT1 in placentas, and maternal and umbilical cord serum of patients with PAS. METHODS: In total, 30 individuals in control, 20 patients in the placenta previa group, and 30 patients in the PAS group were included in this study. The expression levels of SIRT1 in the placentas were determined by Western blot and immunohistochemistry. Serum levels of SIRT1 in maternal and umbilical cord blood were determined by ELISA. RESULTS: SIRT1 was significantly lower in placentas of the PAS. However, maternal and umbilical cord serum samples were not significantly different between groups. CONCLUSION: SIRT1 may play an important role in the pathogenesis of the PAS.
No takes yet. Share an insight, caveat, or question.
Taşkın et al. (2024) conducted an observational in Placenta accreta spectrum (n=80). Placenta accreta spectrum vs. Controls and placenta previa was evaluated on Expression level of SIRT1 in placentas, maternal and umbilical cord serum. SIRT1 expression was significantly lower in the placentas of patients with placenta accreta spectrum, while maternal and umbilical cord serum levels were not significantly different between groups.
Synapse has enriched 10 related papers. Consider them for comparative context: