Key result
Pregnancy is associated with a 4- to 5-fold increased risk of thromboembolism, and observational studies demonstrate the benefit of heparins in reducing the risk of recurrent events.
Why the study?
Does anticoagulation with heparins prevent recurrent thromboembolism in pregnant women at risk?
Does anticoagulation with heparins prevent recurrent thromboembolism in pregnant women at risk?
Heparins are beneficial for reducing recurrent thromboembolism risk in pregnant women, though current recommendations rely heavily on observational data and expert opinion.
May support heparin use in pregnancy-associated thromboembolism risk; leaves open confirmation via randomized trials.
During pregnancy, women have a 4- to 5-fold increased risk of thromboembolism. Candidates for anticoagulation in pregnancy include women with current thrombosis, a history of thrombosis, risk factors for postpartum thrombosis, and some women with thrombophilia and a history of poor pregnancy outcome. Although, there are no large trials of anticoagulants in pregnancy and recommendations for their use are based on case series and the opinion of experts, observational studies demonstrate the benefit of heparins in reducing the risk of recurrent thromboembolism in pregnancy. A practical approach to the prevention and treatment of thromboembolism in pregnancy is outlined.
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Allison James (2012) conducted a review in Venous Thromboembolism in Pregnancy. Heparins was evaluated. Pregnancy is associated with a 4- to 5-fold increased risk of thromboembolism, and observational studies demonstrate the benefit of heparins in reducing the risk of recurrent events.
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