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May 26, 2025Diagnostic PathologyOpen Access

A 19-year-old woman with extensive pelvic disease was diagnosed with a low-grade spindle cell sarcoma harboring a MEIS1::NCOA1 fusion and strong diffuse ER/PR expression.

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Population

A 19-year-old woman with pelvic low-grade spindle cell sarcoma

Design

Case report and review of the literature

Key result

A 19-year-old woman with extensive pelvic disease was diagnosed with a low-grade spindle cell sarcoma harboring a MEIS1::NCOA1 fusion and strong diffuse ER/PR expression.

Authors

MRMadhurya RamineniYAYoungeun ArmbusterHKHani Katerji

Discussion

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Member takes

Overview

MEIS1::NCOA1 fusion merits inclusion in the differential for ER/PR+ pelvic spindle cell sarcomas; leaves open its diagnostic specificity and management implications.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 19-year-old woman presenting with a complex pelvic mass and extensive abdominal disease diagnosed with a MEIS1::NCOA1 fusion sarcoma.
I
Intervention
Diagnostic laparoscopy, pathologic examination, and molecular testing (Mayo Complete Sarcoma Panel)

This case highlights the diagnostic and management challenges of rare MEIS1::NCOA1 fusion spindle cell tumors with suspected gynecologic origin in young adults, emphasizing the need for molecular testing.

Limitations

  • Single case report
  • Initial workup did not include BCOR and beta-catenin IHC stains
  • Deferral of total abdominal hysterectomy and bilateral salpingo-oophorectomy limited complete evaluation of the gynecologic tract and precluded definitive staging
  • Total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH+BSO) was deferred, limiting complete evaluation of the gynecologic tract and precluding definitive staging

Cite This Study

Ramineni et al. (2025) conducted a case report in Pelvic MEIS1::NCOA1 fusion sarcoma (n=1). Diagnostic laparoscopy and molecular profiling was evaluated. A 19-year-old woman with extensive pelvic disease was diagnosed with a low-grade spindle cell sarcoma harboring a MEIS1::NCOA1 fusion and strong diffuse ER/PR expression.

synapsesocial.com/papers/6a9dd0d90ba868d22fa5895chttps://doi.org/10.1186/s13000-025-01656-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spindle Cell Sarcoma of the Uterine Corpus With Adipose Metaplasia: Expanding the Morphologic Spectrum of Neoplasms With MEIS1-NCOA2 Gene Fusion2021 · 19 citations
  2. 2Low-grade undifferentiated sarcoma with MEIS1::NCOA2-rearrangement primary to the lung: a case report2024 · 8 citations
  3. 3MEIS1::NCOA2 Fusion Sarcoma of the Bartholin Gland: A Case Report and Review of the Literature2026 · 1 citations
  4. 41127 Case of 19 year old with malignant spindle cell neoplasm; pelvic monophasic synovial sarcoma arising from the pelvis soft tissues and ligaments2024
  5. 5Novel EWSR1::HOXB8 fusion identified in a rare spindle cell sarcoma of a young woman2026