What is the clinical evidence from this study?

Study design: Review. Population: Heart Failure. Intervention: Body composition assessment.

What question did this study set out to answer?

To develop a phenotype-informed framework that resolves discrepancies in anthropometric metrics by integrating adiposity, fluid accumulation, and muscle integrity in heart failure.

September 1, 2026Journal of Cardiac FailureOpen Access

A phenotype-informed body composition framework in HF reveals similar BMI values mask distinct risk profiles.

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Why the study?

In established HF, BMI shows an apparent discrepancy with waist-based measures and reflects a composite of adipose tissue, fluid accumulation, and skeletal muscle wasting, complicating body composition interpretation.

Population

Patients with established HF

Design

Narrative review

Key result

A phenotype-informed framework for body composition in heart failure suggests that similar BMI values may represent biologically distinct phenotypes with different risk profiles.

Authors

CHCamilla C.S. van der Hoef JMJozine M. ter Maaten LMLaura M.G. Meems

Discussion

Member takes

Overview

May warrant caution using BMI alone for risk stratification in heart failure; leaves open prospective validation of phenotype-informed body composition assessment.

Key Points

To develop a phenotype-informed framework that resolves discrepancies in anthropometric metrics by integrating adiposity, fluid accumulation, and muscle integrity in heart failure.
Reviewed literature evaluating body mass index (BMI) and waist-based measures in relation to survival outcomes in heart failure.
Synthesized physiological interactions among adipose tissue distribution, fluid congestion, and skeletal muscle wasting to construct a clinical classification framework.
Standard BMI conflates adipose tissue, fluid accumulation, and muscle wasting, masking clinically distinct patient risk profiles.
Preserved skeletal muscle mass and absence of congestion correlate with favorable outcomes, whereas central adiposity, fluid congestion, and muscle wasting define high-risk phenotypes across all BMI categories.

Structured PICO

Population

Patients with established heart failure

Exposure

Phenotype-informed framework for body composition assessment and management

This review proposes a phenotype-informed framework for assessing body composition in heart failure, emphasizing that BMI alone masks distinct clinical phenotypes defined by adiposity, congestion, and muscle mass.

Cite This Study

Hoef et al. (2026) conducted a review in Heart Failure. Body composition assessment was evaluated. A phenotype-informed framework for body composition in heart failure suggests that similar BMI values may represent biologically distinct phenotypes with different risk profiles.

synapsesocial.com/papers/6a9dd8aec125c9db8cc950c4 https://doi.org/10.1016/j.cardfail.2026.08.018

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September 1, 2026Journal of Cardiac FailureOpen Access

A phenotype-informed body composition framework in HF reveals similar BMI values mask distinct risk profiles.

View Full Paper

Ask AI

Bookmark

Why the study?

Population

Patients with established HF

Design

Narrative review

Key result

A phenotype-informed framework for body composition in heart failure suggests that similar BMI values may represent biologically distinct phenotypes with different risk profiles.

Authors

CHCamilla C.S. van der Hoef JMJozine M. ter Maaten LMLaura M.G. Meems

Discussion

Member takes

Overview

May warrant caution using BMI alone for risk stratification in heart failure; leaves open prospective validation of phenotype-informed body composition assessment.

Key Points

To develop a phenotype-informed framework that resolves discrepancies in anthropometric metrics by integrating adiposity, fluid accumulation, and muscle integrity in heart failure.
Reviewed literature evaluating body mass index (BMI) and waist-based measures in relation to survival outcomes in heart failure.
Synthesized physiological interactions among adipose tissue distribution, fluid congestion, and skeletal muscle wasting to construct a clinical classification framework.
Standard BMI conflates adipose tissue, fluid accumulation, and muscle wasting, masking clinically distinct patient risk profiles.
Preserved skeletal muscle mass and absence of congestion correlate with favorable outcomes, whereas central adiposity, fluid congestion, and muscle wasting define high-risk phenotypes across all BMI categories.

Structured PICO

Population

Patients with established heart failure

Exposure

Phenotype-informed framework for body composition assessment and management

Cite This Study

synapsesocial.com/papers/6a9dd8aec125c9db8cc950c4 https://doi.org/10.1016/j.cardfail.2026.08.018

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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