Bioelectrical impedance analysis of body composition and survival in patients with heart failure
Key result
Higher indexed body fat mass was associated with improved 5-year survival compared to lower indexed body fat mass in heart failure patients (90.2% vs 80.1%, P=0.008).
Why the study?
Higher BMI is associated with improved prognosis in heart failure, but whether muscle mass rather than adipose tissue accounts for this obesity paradox remains uncertain.
Are higher body fat mass and lean body mass associated with improved survival in outpatients with heart failure?
Population
359 outpatients with HF
Comparison
Stratification by median fat and lean mass indexed by height
Design
Cohort study
Follow-up
5 years
Authors
Discussion
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Member takes
Overview
Associated higher fat mass survival benefit warrants no practice change; extends obesity paradox data but leaves causality open.
Study Design
Type
Cohort (n=359)
Structured PICO
Are higher body fat mass and lean body mass associated with improved survival in outpatients with heart failure?
P
Population
359 outpatients with heart failure, mean age 56 ± 14 years, mean left ventricular ejection fraction 38 ± 16%
I
Intervention
Higher indexed body fat mass and higher indexed lean body mass (measured via bioelectrical impedance analysis)
C
Comparator
Lower indexed body fat mass and lower indexed lean body mass
O
Outcome
5-year survivalhard clinical
Main Result
Effect estimate: HR 0.89
Absolute Event Rate: 90.2% vs 80.1%
p-value: p=0.008
Higher body fat mass and, to a lesser extent, higher lean mass are associated with improved 5-year survival in heart failure outpatients, providing further evidence for the obesity paradox.
Cite This Study
Thomas et al. (2018) conducted a cohort in Heart failure (n=359). High indexed body fat mass vs. Low indexed body fat mass was evaluated on 5-year survival (HR 0.89, p=0.008). Higher indexed body fat mass was associated with improved 5-year survival compared to lower indexed body fat mass in heart failure patients (90.2% vs 80.1%, P=0.008).