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The compound AK34, derived from Tripolin A, shows a pronounced inhibitory effect on Aurora A kinase with high affinity (IC 50 = 1.68 μM, K D = 216 nM). SAR and molecular docking indicate that these ( E )-3-benzylideneindolin-2-one derivatives tend to act on an allosteric Site 3 predicted by AlloReverse.
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Jiao et al. (2024) studied this question.
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