Key result
Non-dipper hypertension was associated with higher serum pentraxin-3 levels compared to dipper hypertension (P=0.028), which negatively correlated with flow-mediated dilation.
Why the study?
Are serum pentraxin-3 levels associated with flow-mediated dilation in patients with dipper and non-dipper hypertension?
Cross-Sectional (n=90)
Are serum pentraxin-3 levels associated with flow-mediated dilation in patients with dipper and non-dipper hypertension?
p-value: p=0.028
Serum pentraxin-3 levels are elevated in non-dipper hypertension and correlate negatively with flow-mediated dilation, suggesting a link to endothelial dysfunction.
May link pentraxin-3 to endothelial dysfunction in non-dipper hypertension; leaves open its clinical utility pending prospective studies.
BACKGROUND: Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin-3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of PTX3 as a diagnostic and prognostic biomarker. We aimed to investigate the relationship between serum PTX3 levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension. METHODS: This study included 90 hypertensive patients were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 38 patients with a dipper pattern and 52 patients with non-dipper pattern. Noninvasive evaluation of the endothelial functions was performed using flow-mediated dilation (FMD) method. RESULTS: Serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension (P = 0.028). In addition, we found negative correlation between serum PTX3 and FMD basal/FMD hyperemia ratio (r = -0.297, P = 0.05 for FMD basal/FMD hyperemia ratio, respectively). CONCLUSIONS: Serum PTX3 levels are closely related with the measures of indirect noninvasive evaluation methods (FMD) in both DH and NDH patients.
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Alp et al. (2018) conducted a cross-sectional in Hypertension (n=90). Non-dipper hypertension pattern vs. Dipper hypertension pattern was evaluated on Serum pentraxin-3 levels (p=0.028). Non-dipper hypertension was associated with higher serum pentraxin-3 levels compared to dipper hypertension (P=0.028), which negatively correlated with flow-mediated dilation.