What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Obesity (n=25). Intervention: Obesity vs. Non-obese. Primary outcome: Plasma PTX3 concentration (ng/ml) (p=<0.01).

January 1, 2010Journal of Atherosclerosis and ThrombosisOpen Access

Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility?

Q: What are the key findings of this study?

Obese men exhibited significantly higher plasma PTX3 concentrations (0.99 vs 0.63 ng/ml) and lower arterial compliance than non-obese men.

View Full Paper

Ask AI

Bookmark

Key result

Obese men exhibited significantly higher plasma PTX3 concentrations (0.99 vs 0.63 ng/ml) and lower arterial compliance than non-obese men.

Why the study?

Does obesity correlate with increased plasma PTX3 concentrations and decreased arterial distensibility in men?

Population

25 men free of overt chronic disease, consisting of 11 obese men and 14 non-obese men.

Design

Cross-sectional

Authors

AMAsako MiyakiUniversity of Tsukuba SMSeiji MaedaPreventive Cardiology MYMutsuko YoshizawaUniversity of Colorado Boulder

Discussion

Member takes

Implication

Supports obesity-PTX3-arterial stiffness link in men; hypothesis-generating, needs prospective confirmation before clinical relevance.

Study Design

Type

Cross-Sectional (n=25)

Multicenter

Structured PICO

Does obesity correlate with increased plasma PTX3 concentrations and decreased arterial distensibility in men?

Population

25 healthy men (11 obese and 14 non-obese) free of chronic disease, non-smokers, and not taking medications, evaluated in a cross-sectional study.

Comparator

Non-obese men (BMI 18 to <30 kg/m²)

Outcome

Carotid arterial compliance, beta-stiffness index, and plasma PTX3 concentrationssurrogate

Main Result

Absolute Event Rate: 0.99% vs 0.63%

p-value: p=<0.01

Obese men exhibit higher circulating PTX3 levels and lower arterial distensibility compared to non-obese men, suggesting a potential link between vascular inflammation and obesity-induced arterial stiffness.

Limitations

BMI is not exactly associated with fat mass, which was not measured.
A significant positive correlation between plasma PTX3 levels and body weight does not prove causation.
Measured plasma levels of PTX3 rather than arterial tissue PTX3 levels.
No significant difference in intima-media thickness (IMT) between non-obese and obese men.
BMI is not exactly associated with fat mass, which is a good indicator of obesity.
No significant correlations were found between plasma PTX3 level and arterial compliance or the beta-stiffness index.
Measured plasma levels of PTX3 rather than arterial tissue levels.

Cite This Study

Miyaki et al. (2010) conducted a cross-sectional in Obesity (n=25). Obesity vs. Non-obese was evaluated on Plasma PTX3 concentration (ng/ml) (p=<0.01). Obese men exhibited significantly higher plasma PTX3 concentrations (0.99 vs 0.63 ng/ml) and lower arterial compliance than non-obese men.

synapsesocial.com/papers/6a9de82051ef4ef99f05546a https://doi.org/10.5551/jat.2741

View Full Paper

Ask AI

Bookmark

Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility?

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility?

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider