What question did this study set out to answer?

To identify the specific anatomic site of secretin-stimulated bile flow and characterize the intracellular signal transduction pathways mediating this choleretic response.

October 1, 1992AJP Gastrointestinal and Liver Physiology

Secretin stimulates bile ductular secretory activity through the cAMP system

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Authors

RLR. LenzenHumboldt-Universität zu Berlin GAGianfranco AlpiniRichard L. Roudebush VA Medical Center NTNicola TavoloniIcahn School of Medicine at Mount Sinai

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Implication

Preclinical study demonstrates that secretin activates ductular bile secretion via cyclic AMP pathways, indicating fluid production does not require inositol phosphate signaling.

Key Points

To identify the specific anatomic site of secretin-stimulated bile flow and characterize the intracellular signal transduction pathways mediating this choleretic response.
Isolated hepatocytes and ductular-enriched nonparenchymal cells from rats with ductular hyperplasia to measure cAMP and inositol phosphate production after treatment with secretin, glucagon, or the selective analog SG-secretin.
Evaluated in vivo biliary secretion of bicarbonate-rich fluid following secretin and SG-secretin administration in rats with bile ductular hyperplasia and in normal guinea pigs.
In isolated bile duct cells, secretin stimulated both cAMP and inositol phosphate formation, whereas SG-secretin exclusively activated cAMP; neither peptide stimulated signaling in hepatocytes, where only glucagon was active.
Both secretin and SG-secretin stimulated bicarbonate-rich fluid secretion originating from the distal biliary epithelium in vivo, demonstrating that ductular secretion is driven primarily by cAMP and does not involve inositol phosphates.

Cite This Study

Lenzen et al. (1992) studied this question.

synapsesocial.com/papers/6a9dec883b6f5c7ac00555bf https://doi.org/10.1152/ajpgi.1992.263.4.g527

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Implication

Preclinical study demonstrates that secretin activates ductular bile secretion via cyclic AMP pathways, indicating fluid production does not require inositol phosphate signaling.

Secretin stimulates bile ductular secretory activity through the cAMP system

Discussion

Member takes

Implication

Key Points

Cite This Study

Secretin stimulates bile ductular secretory activity through the cAMP system

Discussion

Member takes

Implication

Key Points

Cite This Study

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