What question did this study set out to answer?

To assess the effects of secretin on bile secretion, biliary erythritol clearance, bile composition, splanchnohepatic hemodynamics, and general liver function.

April 1, 1978Acta Physiologica Scandinavica

The effect of secretin on bile production, splanchnohepatic hemodynamics and liver function in cats

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Authors

JLJens Anker LarsenAarhus University NKNiels KrarupNovo Nordisk (Denmark)

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Implication

Experimental animal study reveals secretin stimulates ductular bicarbonate-rich bile secretion without altering hemodynamics in cats, indicating direct modulation of bile duct fluid transport.

Key Points

To assess the effects of secretin on bile secretion, biliary erythritol clearance, bile composition, splanchnohepatic hemodynamics, and general liver function.
Administered intravenous secretin at a dose of 2 U·kg⁻¹·h⁻¹ to fasting, chloralose-anesthetized cats.
Evaluated bile flow, biliary clearance of 14C-erythritol, bile composition, hemodynamics, and overall liver function in the presence and absence of indomethacin.
Secretin increased bile flow from below to above baseline 14C-erythritol clearance levels, shifting ductular fluid handling from net reabsorption to net secretion of bicarbonate-rich fluid without changing erythritol clearance.
Secretin infusion caused no significant changes in splanchnohepatic hemodynamics or overall liver function.
Pretreatment with indomethacin did not significantly modify the biliary response to secretin.

Cite This Study

Larsen et al. (1978) studied this question.

synapsesocial.com/papers/6aa8f6f83319b89d68299d8b https://doi.org/10.1111/j.1748-1716.1978.tb06089.x

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Implication

Experimental animal study reveals secretin stimulates ductular bicarbonate-rich bile secretion without altering hemodynamics in cats, indicating direct modulation of bile duct fluid transport.

The effect of secretin on bile production, splanchnohepatic hemodynamics and liver function in cats

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of secretin on bile production, splanchnohepatic hemodynamics and liver function in cats

Discussion

Member takes

Implication

Key Points

Cite This Study

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