Four cases of brain tumor—three meningiomas and one glioblastoma—that developed after radiation therapy are reported. The location and course of each tumor were highly suggestive of a pathogenetic role of the preceding irradiation in the development of the tumor. A review of the literature revealed that there is evidence for a causative role of irradiation in the development of brain tumors, although there has been no definitive epidemiological study.
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Okamoto et al. (1985) studied this question.