Key result
Among children with Guillain-Barré syndrome, the AMAN subtype was significantly associated with preceding diarrheal illness (57.9% vs 4.7%, P=0.007) and IgG GD1b antibodies compared to the AIDP subtype.
Population
43 children with Guillain-Barré syndrome (GBS), male to female ratio 2.1:1.
Design
Cohort
Authors
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Does not yet alter pediatric GBS management; leaves open validation of AMAN triggers in larger cohorts.
Observational (n=43)
Absolute Event Rate: 57.9% vs 4.7%
p-value: p=0.007
In pediatric GBS in the Indian subcontinent, the AMAN subtype is common and associated with preceding diarrhea and specific antiganglioside antibodies, though recovery is complete regardless of subtype.
Kannan et al. (2011) conducted an observational in Childhood Guillain-Barré syndrome (n=43). Acute motor axonal neuropathy (AMAN) subtype vs. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) subtype was evaluated on Preceding diarrheal illness (p=0.007). Among children with Guillain-Barré syndrome, the AMAN subtype was significantly associated with preceding diarrheal illness (57.9% vs 4.7%, P=0.007) and IgG GD1b antibodies compared to the AIDP subtype.
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