Key result
Hyper-reflexic human detrusor muscle showed a significant reduction in cholinergic receptors and an increase in alpha adrenergic receptors compared to normal detrusor.
Observational
Hyper-reflexic human detrusor muscle shows altered autonomic receptor density, specifically decreased cholinergic and increased alpha-adrenergic receptors.
May guide alpha-adrenergic targeting in detrusor hyperreflexia; hypothesis-generating and should not yet change practice.
The density of cholinergic and of alpha and beta adrenergic receptors was measured in samples of normal and hyper-reflexic human detrusor muscle. There was a significant reduction in the density of cholinergic receptors and a significant increase in the density of alpha adrenergic receptors in the hyper-reflexic samples as compared with normal. There was no difference between the two groups in the density of beta adrenergic receptors.
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Restorick et al. (1989) conducted an observational in Hyper-reflexic human detrusor. Hyper-reflexic detrusor muscle vs. Normal detrusor muscle was evaluated on Density of cholinergic and alpha and beta adrenergic receptors. Hyper-reflexic human detrusor muscle showed a significant reduction in cholinergic receptors and an increase in alpha adrenergic receptors compared to normal detrusor.
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