Key result
A high-fat diet for 68 days increased heart mass in both strains, but increased gene expression of innate immune components and inflammatory cytokines only in C57BL/6 mice.
Why the study?
Differences in cardiac tropism and innate immune system modulation between C57BL/6 and FVB/N mouse strains under metabolic stress are not clear.
Does a high-fat diet differentially modulate cardiac inflammatory status and hypertrophy in C57BL/6 versus FVB/N mouse strains?
Population
C57BL/6 and FVB/N mouse strains
Comparison
C57BL/6 mice vs FVB/N mice receiving a high-fat diet
Design
Preclinical animal study
Follow-up
68 days
Authors
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Strain differences in diet-induced cardiac inflammation leave open whether innate immunity drives hypertrophy across models or in humans.
Does a high-fat diet differentially modulate cardiac inflammatory status and hypertrophy in C57BL/6 versus FVB/N mouse strains?
Diet-induced obesity triggers a more robust innate immune and inflammatory response in the hearts of C57BL/6 mice compared to FVB/N mice, despite both developing cardiac hypertrophy.
Gaisler-Silva et al. (2021) studied Obesity-induced cardiac hypertrophy. High-fat diet vs. FVB/N vs C57BL/6 strains was evaluated on Heart mass, gene expression of innate immune components and inflammatory cytokines. A high-fat diet for 68 days increased heart mass in both strains, but increased gene expression of innate immune components and inflammatory cytokines only in C57BL/6 mice.
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