Why the study?
Does obesity reduction improve left ventricular ejection fraction and attenuate LV remodeling, oxidative stress, and inflammation in obese mice?
Population
8-week-old male C57BL/6 J mice (n=24), weighing 22-24 g.
Comparison
Obese reduction diet. vs Control group and Obesity group.
Design
Preclinical, Equally divided, Echocardiography performed by an animal…
Follow-up
22 weeks
Authors
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May support LVEF recovery with weight reduction in obese models; hypothesis-generating and leaves clinical translation open.
Does obesity reduction improve left ventricular ejection fraction and attenuate LV remodeling, oxidative stress, and inflammation in obese mice?
Weight reduction in obese mice significantly reverses impaired left ventricular ejection fraction, adverse remodeling, inflammation, oxidative stress, and apoptosis.
Wang et al. (2012) studied this question.
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