Key result
Switching to a low-fat diet in obese mice with heart failure decreased cardiac hypertrophy and improved both cardiac insulin sensitivity and diastolic function compared with maintaining a high-fat diet.
Why the study?
Does weight loss via a low-fat diet improve cardiac function and metabolism in obese mice with diastolic heart failure?
Population
Obese mice with diastolic heart failure induced by high-fat diet and abdominal aortic constriction
Comparison
Switch to low-fat diet for 10 weeks vs Maintained on high-fat diet for 10 weeks
Design
Preclinical
Follow-up
10 weeks after diet switch (18 weeks total)
Authors
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Should not yet change dietary practice in obese HFpEF; leaves open translation of metabolic benefits from murine models.
Does weight loss via a low-fat diet improve cardiac function and metabolism in obese mice with diastolic heart failure?
In a murine model of obesity and heart failure, weight loss via dietary modification improved diastolic function and cardiac insulin sensitivity, suggesting weight loss is not detrimental in this setting.
Sankaralingam et al. (2014) studied Obese mice with diastolic heart failure. Low-fat (LF) diet vs. High-fat (HF) diet (60% kcal from fat) was evaluated on Cardiac function and metabolism (diastolic function, cardiac hypertrophy, insulin-stimulated glucose oxidation). Switching to a low-fat diet in obese mice with heart failure decreased cardiac hypertrophy and improved both cardiac insulin sensitivity and diastolic function compared with maintaining a high-fat diet.
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