Key result
Diet-induced obesity in mice increased cardiac hypertrophy, macrophage density, and adverse left ventricular remodeling, while reducing collagen deposition after myocardial ischemia-reperfusion injury.
Why the study?
Does diet-induced obesity worsen inflammation and adverse remodeling after myocardial ischemia-reperfusion injury in mice?
Does diet-induced obesity worsen inflammation and adverse remodeling after myocardial ischemia-reperfusion injury in mice?
Diet-induced obesity in mice exacerbates inflammation and adverse left ventricular remodeling following myocardial ischemia-reperfusion injury.
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Caution against extrapolating murine findings to patients; leaves open obesity's role in human post-MI remodeling.
Thakker et al. (2006) studied Myocardial ischemia-reperfusion injury. Diet-induced obesity vs. Lean mice was evaluated on Inflammatory and healing response (chemokines, cytokines, macrophage/neutrophil density, collagen deposition, LV remodeling). Diet-induced obesity in mice increased cardiac hypertrophy, macrophage density, and adverse left ventricular remodeling, while reducing collagen deposition after myocardial ischemia-reperfusion injury.
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