Increased Myocardial Susceptibility to Repetitive Ischemia With High‐fat diet‐induced Obesit
Population
Diet-induced obese (DIO) C57BL/6J mice
Comparison
15 min of daily repetitive ischemia and… vs Lean control mice
Design
Preclinical
Follow-up
5 days
Authors
Discussion
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Implication
Obesity may heighten repetitive I/R injury risk; hypothesis-generating for human metabolic cardiomyopathy and requires clinical validation.
Structured PICO
P
Population
Diet-induced obese (DIO) C57BL/6J mice
I
Intervention
15 min of daily repetitive ischemia and reperfusion (I/R) for 3 or 5 days
C
Comparator
Lean control mice
O
Outcome
Myocardial injury, cardiac lipids, candidate gene expression, and histology at 3 or 5 dayssurrogate
Diet-induced obesity exacerbates myocardial injury and maladaptive metabolic changes following repetitive ischemia and reperfusion in a mouse model.
Cite This Study
Thakker et al. (2008) studied this question.