Key result
Heart failure with normal ejection fraction is a prevalent and complex syndrome with high morbidity and mortality, for which diagnosis relies on clinical signs, echocardiography, and biomarkers, though specific evidence-based treatments remain limited.
This review provides a comprehensive overview of the diagnosis, pathophysiology, and pragmatic management of heart failure with normal ejection fraction based on updated ESC guidelines.
Supports ESC-guided HFpEF diagnosis in practice; leaves open targeted therapies for this high-morbidity syndrome.
A significant proportion of patients with heart failure happen to have a normal ventricular ejection fraction at echocardiography during examination. Previously called diastolic heart failure, it is nowadays referred to as heart failure with normal ejection fraction (HFNEF) or HF with preserved ejection fraction. The European Society of Cardiology, recognizing the importance of this type of heart failure, recently issued new definition criteria for it. This review will discuss the different steps that lead to such a diagnosis, as well as some new aspects of its pathophysiology. Finally, the management of this form of HF, that is not as straightforward as HF due to systolic dysfunction, will be discussed.
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Blanche et al. (2010) conducted a review in Heart failure with normal ejection fraction (HFNEF). Heart failure with normal ejection fraction is a prevalent and complex syndrome with high morbidity and mortality, for which diagnosis relies on clinical signs, echocardiography, and biomarkers, though specific evidence-based treatments remain limited.
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