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July 22, 2021European Journal of Endocrinology

Adrenal ganglioneuromas: a retrospective multicentric study of 104 cases from the COMETE network

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Key result

Surgery for adrenal ganglioneuromas resulted in 0% postoperative recurrence among 42 patients with imaging follow-up over a mean of 29.6 months.

Why the study?

Adrenal ganglioneuromas are rare tumors with limited information derived mostly from small case series.

Population

104 patients with adrenal ganglioneuromas

Design

Retrospective multicenter study

Follow-up

Median 18 months (4-156)

Authors

EDElisa DeflorenneMPMichel PeuchmaurDVDelphine Vezzosi

Discussion

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Overview

May support abbreviated surveillance after resection; leaves open confirmation in larger prospective cohorts.

Study Design

Type

Observational (n=104)

Multicenter

Yes

Structured PICO

P
Population
104 patients with adrenal ganglioneuromas (59.6% female, median age 29 years) who underwent surgery, with imaging follow-up available for 42 patients over a mean of 29.6 months.
E
Exposure
Surgery (complete resection)
O
Outcome
Postoperative recurrencehard clinical

Adrenal ganglioneuromas are large, mostly nonfunctioning tumors that do not appear to require long-term follow-up after complete surgical resection due to the absence of recurrence.

Limitations

  • Duration of follow-up was limited
  • duration of follow-up was limited

Cite This Study

Deflorenne et al. (2021) conducted an observational in Adrenal ganglioneuromas (n=104). Surgery was evaluated on Postoperative recurrence. Surgery for adrenal ganglioneuromas resulted in 0% postoperative recurrence among 42 patients with imaging follow-up over a mean of 29.6 months.

synapsesocial.com/papers/6a9dfa463472a2bf0210598dhttps://doi.org/10.1530/eje-20-1049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult1998 · 88 citations
  2. 2Primary adrenal ganglioneuroma: CT findings in four patients.1997 · 64 citations
  3. 3Biochemical and Clinical Manifestations of Dopamine-Producing Paragangliomas: Utility of Plasma Methoxytyramine2005 · 238 citations
  4. 4Adrenal and extra-adrenal retroperitoneal ganglioneuroma: imaging findings in 13 adults.1997 · 132 citations
  5. 5Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project2011 · 530 citations