Key result
A 95-nt hairpin composed of six copies of a repeating structural subunit was identified within the 190-nt packaging signal domain conserved in all group IIa coronaviruses.
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May suggest packaging-targeted antivirals for group IIa coronaviruses; leaves open functional validation and therapeutic translation.
A 190-nucleotide (nt) packaging signal (PS) located in the 3' end of open reading frame 1b in the mouse hepatitis virus, a group IIa coronavirus, was previously postulated to direct genome RNA packaging. Based on phylogenetic data and structure probing, we have identified a 95-nt hairpin within the 190-nt PS domain which is conserved in all group IIa coronaviruses but not in the severe acute respiratory syndrome coronavirus (group IIb), group I coronaviruses, or group III coronaviruses. The hairpin is composed of six copies of a repeating structural subunit that consists of 2-nt bulges and 5-bp stems. We propose that repeating AA bulges are characteristic features of group IIa PSs.
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Chen et al. (2007) studied Group IIa coronaviruses. A 95-nt hairpin composed of six copies of a repeating structural subunit was identified within the 190-nt packaging signal domain conserved in all group IIa coronaviruses.
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