Key result
The minor allele of SNP rs13376333 in KCNN3 was significantly associated with an increased risk of lone atrial fibrillation (OR 3.02) and structural atrial fibrillation (OR 2.18) in a Taiwanese population.
Why the study?
Does the minor allele of SNP rs13376333 in KCNN3 increase the risk of lone and structural atrial fibrillation in a Taiwanese population?
Case-Control (n=1,072)
No
Does the minor allele of SNP rs13376333 in KCNN3 increase the risk of lone and structural atrial fibrillation in a Taiwanese population?
The minor allele of SNP rs13376333 in KCNN3 is significantly associated with an increased risk of both lone and structural atrial fibrillation in a Taiwanese population, extending findings previously observed in European cohorts.
Associated with higher AF risk in Taiwanese; extends European data but leaves clinical utility open pending validation.
BACKGROUND: A recent study in individuals of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (KCNN3) on chromosome 1q21 with lone atrial fibrillation (AF), indicating a common genetic basis for AF. The aim of the present study was to investigate whether this association between SNP rs13376333 and AF also exists in Taiwanese subjects. METHODS AND RESULTS: The SNP rs13376333 was compared in 214 lone AF patients (58.3±11.4 years) vs. 214 controls (57.7±13.2 years), and in 322 structural AF patients (69.6±13.7 years) vs. 322 controls (68.4±14.2 years) in a Taiwanese population, in a case-control design. The associations between SNP rs13376333 in KCNN3 and structural or lone AF were significant. In the lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6% compared with 3.0% in the controls (P<0.001; odds ratio [OR], 3.02; 95% confidence interval [CI]: 1.54-6.29). The frequency of the minor allele of SNP rs13376333 was 6.5% in structural AF patients compared with 3.1% in controls (P=0.004; OR, 2.18; 95%CI: 1.23-3.96). CONCLUSIONS: There are significant associations between SNP rs13376333 and the risk of developing both lone and structural AF in the Taiwanese population. The minor allele frequency of SNP rs13376333 was much lower in the Taiwanese population compared to that in the Caucasian population.
No takes yet. Share an insight, caveat, or question.
Chang et al. (2011) conducted a case-control in Atrial Fibrillation (n=1,072). SNP rs13376333 minor allele T vs. Controls without atrial fibrillation was evaluated on Lone atrial fibrillation (OR 3.02, 95% CI 1.54-6.29, p=<0.001). The minor allele of SNP rs13376333 in KCNN3 was significantly associated with an increased risk of lone atrial fibrillation (OR 3.02) and structural atrial fibrillation (OR 2.18) in a Taiwanese population.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: