Key result
T allele carriers of the KCNN3 rs13376333 polymorphism were significantly associated with an increased risk of lone AF in the Chinese Han population (OR 2.31; 95% CI 1.41-3.78; p=0.001).
Why the study?
Are KCNN3 gene SNPs rs13376333 and rs1131820 associated with atrial fibrillation in the Chinese Han population?
Case-Control (n=1,904)
Are KCNN3 gene SNPs rs13376333 and rs1131820 associated with atrial fibrillation in the Chinese Han population?
Odds Ratio: 2.31 (95% CI 1.41–3.78)
Absolute Event Rate: 7.6% vs 3.6%
p-value: p=0.001
The KCNN3 rs13376333 polymorphism is associated with lone atrial fibrillation in the Chinese Han population, suggesting the T allele may be an independent predictive factor.
Should not yet inform lone AF risk assessment; leaves open replication of KCNN3 rs13376333 association across populations.
BACKGROUND: The small conductance calcium-activated potassium, subfamily N, member 3 (KCNN3) gene rs13376333 and rs1131820 have been shown to be strongly associated with lone atrial fibrillation (AF), while replication association studies between rs13376333 in KCNN3 gene and risk of AF showed conflicting results. The current study tried to validate the impact of SNP rs13376333 and rs1131820 of KCNN3 gene on the risk of AF in the Chinese Han population. METHODS: A total of 889 AF patients and 1015 controls were enrolled. Two hundred and seventy-eight cases of AF were lone AF. KCNN3 gene SNP rs13376333 and rs1131820 were genotyped by allele-specific MALDI-TOF mass spectrometry. RESULTS: The genotype distribution and allele frequency of rs13376333 polymorphism were not different between total AF patients and controls. However, the genotype distribution of rs13376333 polymorphism was significantly different between lone AF and control group (p<0.001); and T allele frequency was significantly higher in lone AF group than that in controls (7.6% vs 3.6%, p<0.001). Multivariable logistic regression analysis showed that T allele carriers of rs13376333 was significantly associated with lone AF (OR=2.31, 95% CI 1.41-3.78, p=0.001). No relationship between rs1131820 polymorphism and total AF or lone AF was found in this study. CONCLUSIONS: KCNN3 rs13376333 polymorphism was associated with lone AF in the Chinese Han population and the T allele carriers may be an independent predictive factor for lone AF.
No takes yet. Share an insight, caveat, or question.
Luo et al. (2014) conducted a case-control in Atrial fibrillation (n=1,904). KCNN3 gene SNP rs13376333 T allele vs. Controls was evaluated on Lone atrial fibrillation (OR 2.31, 95% CI 1.41-3.78, p=0.001). T allele carriers of the KCNN3 rs13376333 polymorphism were significantly associated with an increased risk of lone AF in the Chinese Han population (OR 2.31; 95% CI 1.41-3.78; p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: