Key result
The rs6771157 C allele in the SCN10A gene was significantly associated with an increased risk of atrial fibrillation in a Chinese Han population (adjusted OR 1.20).
Why the study?
Is the SCN10A rs6771157 polymorphism associated with an increased risk of atrial fibrillation in a Chinese Han population?
Case-Control (n=2,300)
No
Is the SCN10A rs6771157 polymorphism associated with an increased risk of atrial fibrillation in a Chinese Han population?
The SCN10A rs6771157 polymorphism is associated with an increased risk of atrial fibrillation in the Chinese Han population, suggesting a genetic predisposition component.
Answers are grounded in this paper and cite their sources.
Supports SCN10A role in AF susceptibility among Chinese Han; hypothesis-generating and requires replication before any clinical consideration.
A recent genome wide associated study in European descent population identified the association of Atrial fibrillation (AF) risk with a single nucleotide polymorphism (SNP) in SCN10A. The aim of this study was to evaluate whether SCN10A polymorphisms are associated with AF risk in the Chinese Han population. A total of 2,300 individuals of Chinese Han origin were recruited and three potentially functional SNPs were genotyped. Logistic regression models were utilized to calculate odds ratios (ORs) at a 95% confidence intervals (CIs). Logistic regression analysis in an additive genetic model revealed that one SNP in SCN10A (rs6771157) was associated with an increased risk of AF (adjusted OR = 1.20, 95% CI: 1.06 - 1.36, P = 0.003). Stratification analysis of several main AF risk factors indicated that the risk associations with rs6771157 were not statistically different among different subgroups. In summary, our study suggests the possible involvement of the SCN10A variant in AF development in Chinese Han populations. Further biological function analyses are required to confirm our finding.
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Fang et al. (2016) conducted a case-control in Atrial fibrillation (n=2,300). rs6771157 C/G polymorphism in SCN10A vs. AF-free controls was evaluated on Risk of atrial fibrillation (OR 1.20, 95% CI 1.06-1.36, p=0.003). The rs6771157 C allele in the SCN10A gene was significantly associated with an increased risk of atrial fibrillation in a Chinese Han population (adjusted OR 1.20).
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