Key result
The rs3807989 SNP in CAV1 was significantly associated with a decreased risk of atrial fibrillation in Chinese Han individuals (adjusted OR 0.75; 95% CI 0.63-0.89; P=0.001).
Why the study?
Is the rs3807989 G/A polymorphism in CAV1 associated with the risk of atrial fibrillation in Chinese Han populations?
Case-Control (n=1,593)
Is the rs3807989 G/A polymorphism in CAV1 associated with the risk of atrial fibrillation in Chinese Han populations?
Odds Ratio: 0.75 (95% CI 0.63–0.89)
p-value: p=0.001
The CAV1 rs3807989 polymorphism is associated with a decreased risk of atrial fibrillation in the Chinese Han population, extending previous findings from European ancestry cohorts.
CAV1 variant linked to lower AF risk in Chinese Han; extends European GWAS signals but leaves replication incomplete for practice.
BACKGROUND: A recent meta-analysis of several genome-wide association studies identified six new susceptibility single nucleotide polymorphisms (SNPs) for atrial fibrillation (AF) in individuals of the European ancestry. We aimed to replicate the associations between these SNPs and the risk of AF in a Chinese Han population. METHODS: We genotyped six SNPs (rs3903239 in PRRX1, rs3807989 in CAV1, rs10821415 in C9orf3, rs10824026 in SYNPO2L, rs1152591 in SYNE2, and rs7164883 in HCN4) using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models. RESULTS: We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Among the six SNPs analyzed in the study, the SNP rs3807989 in CAV1 on chromosome 7q31 was found to be significantly associated with a decreased risk of AF (crude OR = 0.76, 95% CI: 0.64-0.89, P = 0.001; adjusted OR = 0.75, 95% CI: 0.63-0.89, P = 0.001). There were no significant associations between the other five loci and AF risk. CONCLUSION: Our results confirmed that CAV1 rs3807989 may contribute to a decreased AF risk in Chinese Han populations. However, further validation studies with different ethnic backgrounds and biological function analyses are warranted to confirm our finding.
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Liu et al. (2014) conducted a case-control in Atrial fibrillation (n=1,593). rs3807989 SNP in CAV1 vs. Non-carriers / Controls without AF was evaluated on Risk of atrial fibrillation (adjusted OR 0.75, 95% CI 0.63-0.89, p=0.001). The rs3807989 SNP in CAV1 was significantly associated with a decreased risk of atrial fibrillation in Chinese Han individuals (adjusted OR 0.75; 95% CI 0.63-0.89; P=0.001).
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