March 10, 2017Scientific ReportsOpen Access

Association of SCN10A Polymorphisms with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population

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Why the study?

Does the SCN10A rs6795970 polymorphism predict AF recurrence after catheter ablation in patients with drug-refractory AF?

Structured PICO

Does the SCN10A rs6795970 polymorphism predict AF recurrence after catheter ablation in patients with drug-refractory AF?

Population

502 consecutive patients with drug-refractory atrial fibrillation (AF) who underwent their first radiofrequency catheter ablation procedure, mean age 60.1 years, 287 males (57.2%), Chinese Han population. Key exclusions: previous endovascular or surgical AF ablation or maze surgery, untreated hyperthyroidism, severe pulmonary disease, severe hepatic and renal dysfunction.

Intervention

SCN10A rs6795970 polymorphism genotyping

Comparator

Different SCN10A rs6795970 genotypes (AA vs. GA vs. GG)

Outcome

AF recurrence (defined as a documented episode of any atrial arrhythmias lasting ≥30 s after a blanking period of 3 months) between 3 and 12 months after catheter ablationhard clinical

The SCN10A rs6795970 polymorphism is an independent predictor of atrial fibrillation recurrence after catheter ablation in the Chinese Han population.

Implication

May inform post-ablation risk stratification in AF; leaves open whether genotyping improves patient selection or outcomes.

Abstract

The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recurrence after catheter ablation. A total of 502 consecutive patients with AF who underwent catheter ablation were included. AF recurrence was defined as a documented episode of any atrial arrhythmias lasting ≥30 s after a blanking period of 3 months. AF recurrence was observed between 3 and 12 months after catheter ablation in 24.5% of the patients. There was a significant difference in the allele distribution (p = 7.86 × 10 −5 ) and genotype distribution (p = 1.42 × 10 −5 ) of rs6795970 between the AF recurrence and no recurrence groups. In a multivariate analysis, we identified the following independent predictors of AF recurrence: the rs6795970 genotypes in an additive model (OR 0.36, 95%CI 0.22~0.60, p = 7.04 × 10 −5 ), a history of AF ≥36 months (OR 3.57, 95%CI 2.26~5.63, p = 4.33 × 10 −8 ) and left atrial diameter (LAD) ≥40 mm (OR 1.85, 95%CI 1.08~3.19, p = 0.026). These data suggest that genetic variation in SCN10A may play an important role in predicting AF recurrence after catheter ablation in the Chinese Han population.