Key result
Heparin-coated surfaces reduced platelet aggregation compared to uncoated tubes, although aggregation still occurred in groove areas not totally coated by heparin.
Why the study?
Does uniform heparin coating on biopolymers reduce platelet aggregation compared to uncoated surfaces in extracorporeal circulation models?
Does uniform heparin coating on biopolymers reduce platelet aggregation compared to uncoated surfaces in extracorporeal circulation models?
Uniform heparin coating is essential for biopolymers used in extracorporeal circulation to minimize platelet aggregation and thrombus formation.
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May warrant uniform heparin coating in animal extracorporeal models; leaves open clinical translation and thrombosis risk.
Moreira et al. (2000) studied this question. Heparin coating vs. Uncoated surfaces was evaluated on Platelet aggregation. Heparin-coated surfaces reduced platelet aggregation compared to uncoated tubes, although aggregation still occurred in groove areas not totally coated by heparin.
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