Why the study?
Does heparin and/or lipid coating of open-heart surgery tubing improve thromboresistance and reduce platelet adhesion in vitro compared to noncoated tubing?
Does heparin and/or lipid coating of open-heart surgery tubing improve thromboresistance and reduce platelet adhesion in vitro compared to noncoated tubing?
Heparin coating of open-heart surgery tubing improves thromboresistance and reduces platelet adhesion in vitro without increasing hemolysis or cytotoxicity.
The aim of this work was to evaluate in vitro the tromboresistence, hemolysis tendency, platelet adhesion, cytotoxicity, physicochemical properties, and stability of open-heart tubing coated with fractionated heparin-benzalkonium chloride and/or lipid dipalmitoyl L-alpha-phosphatidylcholine (DPPC). The tendency for clot formation and platelet adhesion was greater in noncoated and lipid-coated tubing than in heparin-coated tubing. There were no significant differences between the hemolytic potentials of coated and noncoated tubing. The coatings were stable during the time of the experiment. The coatings did not present cytotoxicity and physicochemical alterations.
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Novello et al. (2000) studied this question.
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