Key result
A simple benzalkonium chloride-heparin precipitate coating delayed fibrin deposition on the outside of catheters for several hours in a canine model.
Why the study?
Does a benzalkonium chloride-heparin precipitate coating prevent fibrin deposition on catheters in a dog model?
Does a benzalkonium chloride-heparin precipitate coating prevent fibrin deposition on catheters in a dog model?
A simple benzalkonium chloride-heparin coating delays fibrin deposition on catheters, offering a potentially easy method to create non-thrombogenic surfaces.
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Hypothesis-generating for antithrombotic catheter coatings; human trials needed before any clinical consideration.
Kurt Amplatz (1971) studied Fibrin deposition on catheters. Benzalkonium chloride-heparin precipitate coating vs. Uncoated control catheters was evaluated on Fibrin deposition on the external surface of catheters. A simple benzalkonium chloride-heparin precipitate coating delayed fibrin deposition on the outside of catheters for several hours in a canine model.
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