Key result
Heparin-bonded catheters effectively prevented catheter-induced platelet activation and fibrin formation compared to conventional catheters during percutaneous cardiac catheterization.
Why the study?
Does heparin bonding of cardiovascular catheters prevent catheter-induced platelet activation and fibrin formation in patients undergoing percutaneous cardiac catheterization?
Population
47 patients undergoing percutaneous cardiac catheterization
Comparison
Heparin-bonded cardiovascular catheters vs Conventional cardiovascular catheters
Design
Cohort
Authors
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Supports accurate in vivo coagulation assessment during catheterization; hypothesis-generating and should not yet change practice.
Does heparin bonding of cardiovascular catheters prevent catheter-induced platelet activation and fibrin formation in patients undergoing percutaneous cardiac catheterization?
Heparin-bonded catheters effectively prevent artifactual catheter-induced platelet activation and fibrin formation, allowing for accurate in vivo assessment of intravascular coagulation.
Nichols et al. (1984) studied Patients undergoing percutaneous cardiac catheterization (n=47). Heparin-bonded catheters vs. Conventional catheters (woven Dacron, polyvinylchloride, and polyurethane) was evaluated on Platelet activation (PF4, BTG, TXB2) and fibrin formation (FPA). Heparin-bonded catheters effectively prevented catheter-induced platelet activation and fibrin formation compared to conventional catheters during percutaneous cardiac catheterization.
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