Key result
Heparin alters platelet release and aggregation versus citrate on vascular grafts in vitro.
Why the study?
The effect of heparin versus citrate anticoagulation on platelet interaction with vascular graft materials is not well understood.
Does heparin compared to citrate affect platelet activation when interacting with vascular graft materials in vitro?
Population
Platelets interacting with ePTFE, Dacron Bionit, and preclotted Dacron Bionit in vitro
Comparison
Heparin anticoagulation vs citrate anticoagulation
Design
In vitro recirculating perfusion system study
Authors
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Does not inform clinical anticoagulation choice; leaves open optimal conditions for modeling graft-platelet interactions in vitro.
Does heparin compared to citrate affect platelet activation when interacting with vascular graft materials in vitro?
In an in vitro perfusion system, heparin and citrate anticoagulation result in significant differences in platelet release and aggregation when exposed to vascular graft materials.
Kottke‐Marchant et al. (1985) studied this question. Heparin vs. Citrate was evaluated on Platelet activation (decrease in platelet count, increase in platelet release, decrease in platelet aggregation). Heparin anticoagulation resulted in significant differences in platelet release and aggregation compared to citrate when interacting with vascular graft materials in an in vitro perfusion system.
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