Why the study?
Does bolus intravenous heparin alter platelet activation in patients with stable CAD undergoing coronary angiography or angioplasty?
Population
32 patients with stable coronary artery disease, including 16 undergoing coronary angiography and 16…
Comparison
Bolus intravenous administration of low-dose… vs Comparison between low-dose and high-dose…
Design
Cohort
Follow-up
Immediate (before and after bolus administration)
Authors
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Low-dose heparin may increase platelet activation during procedures; hypothesis-generating for optimal dosing in stable CAD.
Does bolus intravenous heparin alter platelet activation in patients with stable CAD undergoing coronary angiography or angioplasty?
Bolus administration of intravenous heparin at clinically relevant anticoagulant concentrations (<0.7 U/mL) paradoxically augments platelet activation, which may have implications for optimal dosing during coronary procedures.
Naqvi et al. (1998) studied this question.
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