Key result
Stabilized heparin coatings and endothelium bind thrombin and accelerate plasma inhibition in vitro.
Population
In vitro model using endothelial surface of segments of the porcine aorta and two heparinized polyethylene…
Comparison
Exposure to two differently heparin-coated… vs Exposure to endothelial lining of porcine aorta…
Design
Preclinical
Authors
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In vitro thrombin-binding data support heparin coating optimization; leaves open in vivo antithrombotic translation.
In vitro, both the endothelium and stabilized heparin coatings bind thrombin and accelerate its inhibition by plasma, supporting the thromboresistant properties of these heparin surfaces.
Arnander et al. (1986) studied this question. Heparin-coated surfaces (ionic and covalent binding) vs. Endothelial surface of porcine aorta was evaluated on Thrombin uptake and inhibition. Stabilized heparin coatings and the endothelium bind thrombin and accelerate its inhibition by plasma in vitro.
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