Key result
Avian lipoprotein lipase SNPs at intron 8 were significantly associated with LDL in fat chickens and with total cholesterol and HDL in both fat and lean chickens (P<0.05).
Cross-Sectional (n=118)
p-value: p=<0.05
In avian models, SNPs in the lipoprotein lipase gene are significantly associated with variations in LDL, HDL, and total cholesterol levels.
Hypothesis-generating in avian models; leaves open relevance to human lipid genetics.
Musa, H.H., Chen, G.H., Bao, W.B., Cheng, J.H. and Mekki, D.M. 2007. Association of SNPs in intron 8 of avian lipoprotein lipase gene with cholesterol, triglyceride and lipoprotein concentrations. J. Appl. Anim. Res., 32: 155–159. A total of 118 blood samples were collected from Anka and Rugao chickens at 12 weeks of age and total cholesterol, triglyceride, HDL, VLDL and LDL were determined. Lipoprotein lipase (LPL) SNPs in Anka and Rugao were detected at 14538bp (C/A) and 14977bp (T/C). Allele frequency was significantly (P<0.01) different in Rugao at LPL10 locus. LPL gene was found to be significantly (P<0.01) different in Anka and Rugao chicken populations. SNPs at LPL9 locus were significantly (P<0.05) associated with LDL in Anka. In addition, total cholesterol and HDL were found to be significantly (P<0.05) different between SNPs genotype at LPL10 locus in both Anka and Rugao chickens. It is concluded that in avian, LPL SNP was significantly associated with LDL in fat chickens and with total cholesterol and HDL in both fat and lean chickens.
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Musa et al. (2007) reported a cross-sectional. LPL gene SNPs (LPL9 and LPL10 loci) was evaluated on Cholesterol, triglyceride and lipoprotein concentrations (p=<0.05). Avian lipoprotein lipase SNPs at intron 8 were significantly associated with LDL in fat chickens and with total cholesterol and HDL in both fat and lean chickens (P<0.05).
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