Key result
Single nucleotide polymorphisms in apoVLDL-II and lipoprotein lipase genes and their interaction significantly affected body weight, fat weight, total cholesterol, and high-density lipoprotein (P < 0.05).
Why the study?
Does the interaction between Lipoprotein Lipase and ApoVLDL-II genes affect fat and serum biochemical levels in chickens?
Observational (n=120)
Does the interaction between Lipoprotein Lipase and ApoVLDL-II genes affect fat and serum biochemical levels in chickens?
p-value: p=<0.05
The interaction between apoVLDL-II and lipoprotein lipase genes significantly affects lipid profiles and body weight in a chicken model.
SNP interactions in apoVLDL-II and LPL affect chicken lipid traits; hypothesis-generating for human cardiometabolic research.
Body weight, abdominal fat weight and serum biochemical levels were determined from lean and fat chicken breeds at 12 weeks of age. Single nucleotide polymorphism (SNP) in apoVLDL-II and lipoprotein lipase genes was screened by PCR-SSCP and detected by direct sequencing. Lipoprotein lipase gene frequency was found to be significantly different (P < 0.01) in lean chicken whereas it was non-significantly different in fat chicken. SNP in apoVLDL-II and lipoprotein lipase genes significantly (P< 0.05) affected body weight and fat weight. Similarly their interaction significantly (P < 0.05) affected body weight and fat weight. However, no significant difference was observed in the percentage of abdominal fat. SNP in apoVLDL-II and lipoprotein lipase genes significantly (P < 0.05) affected total cholesterol and high density lipoprotein. More likely, the interaction of apoVLDL-II and lipoprotein lipase significantly affect total cholesterol, triglyceride, high density lipoprotein, very low density lipoprotein and low density lipoprotein.
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Musa et al. (2007) conducted an observational in Lean and fat chicken breeds (n=120). SNPs in apoVLDL-II and lipoprotein lipase genes vs. Different genotypes was evaluated on Body weight, fat weight, and serum biochemical levels (p=<0.05). Single nucleotide polymorphisms in apoVLDL-II and lipoprotein lipase genes and their interaction significantly affected body weight, fat weight, total cholesterol, and high-density lipoprotein (P < 0.05).
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