Kinetic studies on the intramolecular titanium-catalyzed hydroaminoalkylation of alkenes (see scheme) are consistent with theoretical results and lead to the conclusion that the rate-determining step of the catalytic cycle is the CH activation at the α position to the nitrogen atom. The reaction has a high activation energy and involves a moderately ordered transition state.
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Prochnow et al. (2011) studied this question.
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