Key result
Increasing extracellular potassium decreases the resting length of rabbit aorta strips and increases sensitivity to l-norepinephrine, while decreasing potassium has opposite effects.
Why the study?
Does altering extracellular potassium concentration affect the resting length and response to l-norepinephrine in rabbit aorta strips?
Population
Helical rabbit aorta strips
Comparison
Changes in concentration of extracellular… vs Normal extracellular potassium concentration
Design
Preclinical
Authors
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Caution against clinical extrapolation from rabbit aorta; leaves open potassium's role in human vascular reactivity.
Does altering extracellular potassium concentration affect the resting length and response to l-norepinephrine in rabbit aorta strips?
Alterations in extracellular potassium concentration directly affect the resting length and sensitivity to l-norepinephrine in rabbit aortic smooth muscle.
Bevan et al. (1963) studied this question. Extracellular potassium concentration changes vs. Normal potassium concentration was evaluated on Change in resting length and response to l-norepinephrine. Increasing extracellular potassium decreases the resting length of rabbit aorta strips and increases sensitivity to l-norepinephrine, while decreasing potassium has opposite effects.
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