New Active‐Site Analogues of Chloraperoxidase—Syntheses and Catalytic Reactions

The iron(III) porphyrin 1 catalyzes the chlorination of activated CH bonds. It is therefore a model compound for the as yet unidentified intermediate of the catalytic cycle of the heme–thiolate protein chloroperoxidase (CPO). Neither “free HOCl” nor Cl• are involved in the CPO-catalyzed chlorination, but rather an iron-bound HOCl is the source of Cl+.