Radiation Chemistry of Dna Components. Formation of the 8,5′-Cyclo-2′,5′-Dideoxyguanosine by Gamma Irradiation of Deaerated Aqueous Solutions of 2′-Deoxyguanosine and Its 5′-Monophosphate Ester

Abstract 8,5′-cyclo-2′,5′-dideoxyguanosine was shown to be produced by gamma irradiation of deaerated aqueous solutions of 2′-deoxyguanosine and 2′-deoxyguanosine-5′-monophosphate, subsequent to initial hydrogen abstraction at the osidic carbon C(4′). Structure assignment was made on the basis of UV, 1H and 13C NMR, mass spectrometry analyses, and confirmed by an independent synthesis.