Key result
Aqueous ANGPTL4 levels were significantly elevated in NPDR patients with DME and positively correlated with foveal/parafoveal retinal thickness and volume, and negatively correlated with deep vessel density (P<0.05).
Why the study?
The study was conducted to investigate aqueous angiogenic factor levels in NPDR patients with DME and evaluate their association with OCTA metrics.
Does the aqueous level of ANGPTL4 correlate with OCTA metrics in patients with nonproliferative diabetic retinopathy and diabetic macular edema?
Cross-Sectional (n=54)
Does the aqueous level of ANGPTL4 correlate with OCTA metrics in patients with nonproliferative diabetic retinopathy and diabetic macular edema?
p-value: p=<0.05
Aqueous ANGPTL4 levels are significantly elevated in NPDR patients with DME and correlate with retinal thickness, volume, and deep vessel density, suggesting a role in DME pathogenesis.
May link aqueous cytokines to OCTA metrics in NPDR/DME; leaves open clinical relevance pending prospective validation.
Purpose. To investigate the aqueous levels of angiogenic factors in nonproliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and to ascertain their association with optical coherence tomography angiography (OCTA) metrics. Methods. This study enrolled 21 NPDR eyes with DME (NPDR/DME+), 17 NPDR eyes without DME (NPDR/DME-), and 16 diabetic eyes without retinopathy (DWR). Luminex bead-based multiplex array was used to measure the levels of 25 cytokines. OCTA system with a scan area of 3 × 3 mm was used to measure retinal thickness (RT), retinal volume (RV), superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ) area, perimeter and acircularity index. Results. The levels of ANGPTL4 were significantly different among the three groups ( P < 0.05 ), in which NPDR/DME+ group had the highest level and NPDR/DME- group had a higher level than the DWR group (all, P < 0.0167 ). OCTA examination showed that, compared with DWR and NPDR/DME- group, RT and RV increased and the whole/parafoveal DVD decreased in NPDR/DME+ group (all, P < 0.05 ). Meanwhile, NPDR/DME- group had lower parafoveal DVD than the DWR group ( P < 0.05 ). Correlation analysis showed that the levels of ANGPTL4 were positively correlated with foveal/parafoveal RT and RV and negatively correlated with whole/parafoveal DVD in NPDR patients (all, P < 0.05 ). As the influencing factor of RT, RV, and DVD, every additional 103 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RT of 4.299 μm and 3.598 μm, respectively. Every additional 106 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RV of 3.371 mm3 and 17.705 mm3, respectively. Every additional 104 pg/ml of ANGPTL4 was associated with a decrease in whole and parafoveal DVD of 1.705% and 1.799%, respectively. Conclusions. The level of ANGPTL4 in aqueous humor of NPDR patients with DME was significantly increased and ANGPTL4 might predict RT, RV, and parafoveal DVD of DME in NPDR patients.
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Xu et al. (2022) conducted a cross-sectional in Nonproliferative diabetic retinopathy (NPDR) with diabetic macular edema (DME) (n=54). Aqueous ANGPTL4 levels vs. Diabetic eyes without retinopathy (DWR) or NPDR without DME was evaluated on Correlation of ANGPTL4 levels with OCTA metrics (retinal thickness, retinal volume, deep vessel density) (p=<0.05). Aqueous ANGPTL4 levels were significantly elevated in NPDR patients with DME and positively correlated with foveal/parafoveal retinal thickness and volume, and negatively correlated with deep vessel density (P<0.05).
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