Key result
Elevated circulating ANGPTL2 levels were significantly associated with the diagnosis and severity of diabetic macular edema in patients with type 2 diabetes (4.46 ng/mL in CSME vs 3.33 ng/mL in controls, P<0.01).
Why the study?
Macular edema is an inflammatory disease characterized by increased microvascular permeability, and the relationship between plasma ANGPTL2 levels and macular edema severity in T2DM patients required investigation.
Are higher levels of circulating ANGPTL2 associated with the presence and severity of macular edema in patients with type 2 diabetes?
Cross-Sectional (n=172)
No
Are higher levels of circulating ANGPTL2 associated with the presence and severity of macular edema in patients with type 2 diabetes?
Absolute Event Rate: 4.46% vs 3.33%
p-value: p=<0.01
Elevated circulating ANGPTL2 levels are independently associated with the presence and severity of diabetic macular edema in patients with type 2 diabetes.
Hypothesis-generating for ANGPTL2 in diabetic macular edema; prospective studies needed before any clinical role.
Macular edema (ME) is an inflammatory disease characterized by increased microvascular permeability. Here, we proposed that plasma angiopoietin-like protein 2 (ANGPTL2) level may be related to the severity of ME patients with type 2 diabetes mellitus (T2DM). In this cross-sectional study, 172 T2DM patients were recruited and divided into clinically significant macular edema (CSME), non-CSME (nCSME), and control groups. Serum ANGPTL2 level was quantified by ELISA and best corrected vision acuity (BCVA) was detected. After adjust age, sex, body mass index (BMI), and duration of diabetes variables, ANGPTL2 performed statistics difference among CSME-, nCSME-groups, and control group (4.46 [3.97, 4.96, 95%CI] ng/mL in CSME group, 3.80 [3.42, 4.18, 95%CI] ng/mL in nCSME-group, 3.33 [3.03, 3.63, 95%CI] ng/mL in control, P < .01). After adjustment of confounding factors, high levels of circulating ANGPTL2 were related with the diagnosis of ME, BCVA, and C reactive protein (CRP) through univariate regression analysis (P < .05). Meanwhile, in the multiple regression model, ANGPTL2 took the mainly effect proportion for the diagnosis of diabetic macular edema (DME), with a LogWorth value 3.559 (P < .001). Our study suggested that elevated circulating ANGPTL2 may be associated with the development of DME and the severity of visual impairment in patients with type 2 diabetes.
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Yin et al. (2021) conducted a cross-sectional in Type 2 diabetes mellitus with or without macular edema (n=172). Circulating ANGPTL2 levels vs. Control group (T2DM without DME) was evaluated on Serum ANGPTL2 level (p=<0.01). Elevated circulating ANGPTL2 levels were significantly associated with the diagnosis and severity of diabetic macular edema in patients with type 2 diabetes (4.46 ng/mL in CSME vs 3.33 ng/mL in controls, P<0.01).
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