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We applied AFM-based single-molecule force spectroscopy to investigate the “unziping” of double-stranded DNA molecules with different sequences. The forces needed to open the double strands showed variations between 10 and 20 pN on a length scale of 10 bases. The force profiles were characteristic for each DNA sequence and could be described quantitatively using a thermodynamic equilibrium model.
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Krautbauer et al. (2003) studied this question.
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