Key result
Enhanced recovery after surgery (ERAS) significantly reduced postoperative hospitalization days, catheter withdrawal times, and inflammatory markers compared to non-ERAS care (P<0.05).
Why the study?
The study was conducted to evaluate the feasibility and necessity of enhanced recovery after surgery (ERAS) in elderly patients with colorectal cancer by assessing inflammatory markers and postoperative complications.
Does enhanced recovery after surgery reduce postoperative stress state and short-term complications in elderly patients with colorectal cancer?
Cohort (n=313)
No
Does enhanced recovery after surgery reduce postoperative stress state and short-term complications in elderly patients with colorectal cancer?
p-value: p=<0.05
Enhanced recovery after surgery (ERAS) optimizes perioperative care, reducing postoperative stress and accelerating recovery in elderly colorectal cancer patients.
May support ERAS to shorten recovery and reduce inflammation; leaves open confirmation in randomized trials.
Objective: To evaluate the feasibility and necessity of enhanced recovery after surgery in elderly patients with colorectal cancer by observing the inflammatory markers and postoperative complications in patients. Methods: Hospitalized Colorectal cancer patients from the Affiliated Hospital of Jiangsu University during 2021.01-2022.09 were collected and these patients were divided into two groups:ERAS group and non-ERAS group. Postoperative inflammatory markers and complications of patients were collected. Results: 313 patients with colorectal cancer were included, There were 182 patients in the ERAS group and 131 in non-ERAS group. The patients in ERAS group was significantly shorter than the non-ERAS group in terms of postoperative hospitalization days, withdrawal time of urinary catheter, withdrawal time of drainage tube, and recovery of bowel function (P<0.05). In terms of hospitalization expenses, the patients in ERAS group were lower than non-ERAS group, the distinction was statistically significant (P<0.05).However, the level of procalcitonin and TNF-α in ERAS group was significantly lower than non-ERAS group on the post-operative day 1, 3 (P<0.05), the level of IL-6 and IL-10 in ERAS group was significantly lower than non-ERAS group on the 1st ,3rd and 5th day after operation (P<0.05). The levels of CRP and WBC in ERAS group were lower than non-ERAS group on the post-operative day 3, 5 (P<0.05). However,hemoglobin levels did not differ significantly(P>0.05). Albumin levels did not differ significantly between the two groups before surgery (P>0.05), but the level of albumin in ERAS group was higher than non-ERAS group on the post-operative day3,5 (P<0.05). ERAS patients had a lower level of albumin after surgery compared to non-ERAS patients (P<0.05). Conclusion: ERAS leads to a series of perioperative optimization measures, thereby reducing the postoperative stress response of elderly colorectal cancer patients and reducing the occurrence of perioperative complications.
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Han et al. (2023) conducted a cohort in Colorectal cancer (n=313). Enhanced recovery after surgery (ERAS) vs. Non-ERAS was evaluated on Postoperative hospitalization days, withdrawal time of urinary catheter/drainage tube, recovery of bowel function, and inflammatory markers (p=<0.05). Enhanced recovery after surgery (ERAS) significantly reduced postoperative hospitalization days, catheter withdrawal times, and inflammatory markers compared to non-ERAS care (P<0.05).