Key result
Titin, microtubules, actin, and the extracellular matrix all significantly influence myocardial passive stiffness, with titin dominating elastic forces and microtubules affecting viscous forces.
This commentary underscores that myocardial passive stiffness is determined by a complex interaction of titin, microtubules, actin, and the extracellular matrix, with titin being the primary driver of elastic forces.
This comment summarizes and discusses the key findings of the recent publication by Loescher, C.M., Freundt, J.K., Unger, A. et al. Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix. Nat Cardiovasc Res 2, 991–1002 (2023). https://doi.org/10.1038/s44161-023-00348-1. It introduces the background of the addressed issue, highlights the strength of the study and discusses remaining questions.
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Martina Krüger (2024) conducted an editorial in Myocardial passive stiffness. Titin, microtubules, actin, and the extracellular matrix all significantly influence myocardial passive stiffness, with titin dominating elastic forces and microtubules affecting viscous forces.
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