Key result
Histopathological and molecular examination of a resected retroperitoneal mass revealed dedifferentiated liposarcoma with a novel aneurysmal bone cyst-like morphology.
Case Report (n=1)
This case represents the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, expanding the known morphological spectrum of this tumor.
May broaden differential for recurrent retroperitoneal masses; leaves open prognostic and therapeutic implications.
A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.
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Haverbeke et al. (2017) conducted a case report in Recurrent retroperitoneal dedifferentiated liposarcoma (n=1). Histopathological and molecular examination was evaluated on Diagnosis of tumor morphology and differentiation. Histopathological and molecular examination of a resected retroperitoneal mass revealed dedifferentiated liposarcoma with a novel aneurysmal bone cyst-like morphology.
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