Association between MCT1 T1470A polymorphism and athlete status in Japanese power-oriented athletes

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BACKGROUND: Previous studies have reported that the MCT1 T1470A polymorphism is associated with lactate metabolism during exercise and performance status of athletes. The purpose of this study was to compare the allele frequency of the MCT1 T1470A polymorphism (rs1049434) between Japanese power-oriented athletes and controls, and to determine the effect of MCT1 T1470A polymorphism on the weightlifting and powerlifting performance.METHODS: Our case-control study consisted of 264 power-oriented athletes including 181 weightlifters, 83 powerlifters, and 649 controls. Total DNA was extracted from saliva samples and the MCT1 T1470A rs1049434 polymorphism was analyzed using a TaqMan probe in a real-time polymerase chain reaction.RESULTS: Weightlifting and powerlifting performance was obtained by recording the personal record for each subject in an official competition using a questionnaire and then converted using the wilks coefficient point in weightlifters and the IPF coefficient point in powerlifters. Consequently, we found that the frequency of T allele was significantly higher in weightlifters than in controls (38% vs. 32%, P=0.02). However, no association was observed between the MCT1 T1470A polymorphism and weightlifting and powerlifting performance.CONCLUSIONS: Our results suggest that the frequency of T allele in the MCT1 T1470A polymorphism is over-represented in weightlifters.