Key result
The AB blood phenotype was associated with statistically significantly lower serum PON1 and ApoA-I levels, and increased OxLDL levels compared to other blood groups.
Why the study?
The impact of different ABO blood phenotypes on HDL functionality had not been extensively investigated.
Does the AB blood phenotype affect HDL functionality markers compared to other blood groups in healthy males?
Cross-Sectional (n=169)
Does the AB blood phenotype affect HDL functionality markers compared to other blood groups in healthy males?
The AB blood phenotype is associated with impaired HDL functionality markers, including lower PON1 and ApoA-I and higher OxLDL, suggesting a potential genetic link to cardiovascular risk.
AB blood group linked to lower PON1/ApoA-I and higher OxLDL; hypothesis-generating for HDL function differences, needs prospective validation.
BACKGROUND: The impact of the different ABO blood phenotypes has not been extensively investigated on high-density lipoprotein (HDL) functionality. Therefore, the aim of this study was to assess HDL-related serum paraoxonase 1 (PON1), ApolipoproteinA-1 (ApoA-I) and also oxidized low-density lipoprotein (OxLDL) in relation to ABO blood groups.SUBJECTS AND METHODS: ABO blood types represent part of the genetic phenotype. Therefore, we assume that ABO blood phenotypes are associated with many diseases. This cross-sectional study involved 169 apparently healthy male medical staff with different ABO blood phenotypes.RESULTS: The most important of the findings in this study is that the amount of PON1, which is one of the valuable markers of HDL function, was statistically significantly lower in people with AB blood group than in other blood groups. Furthermore, one notable important findings of this study are the lowest serum ApoA-I levels of individuals in AB blood phenotype. On the contrary, serum OxLDL levels in the subjects with AB blood phenotype are increased.CONCLUSION: There is no doubt that it is necessary to examine in more detail the molecular changes in HDL metabolism linked to the ABO blood group phenotype. What is really interesting is that the AB blood phenotype in many Mediterranean countries has the lowest rate of distribution. According to the findings from this study, the A and B blood group phenotypes may be more effective than expected in disease susceptibility.
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Yılmaz et al. (2020) conducted a cross-sectional in Healthy (n=169). AB blood phenotype vs. Other ABO blood groups was evaluated on Serum paraoxonase 1 (PON1), ApolipoproteinA-1 (ApoA-I), and oxidized low-density lipoprotein (OxLDL) levels. The AB blood phenotype was associated with statistically significantly lower serum PON1 and ApoA-I levels, and increased OxLDL levels compared to other blood groups.
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