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June 17, 2020European Journal of Preventive CardiologyOpen Access

Screening for coronary artery calcium in a high-risk population: the ROBINSCA trial

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Key result

In a high-risk asymptomatic population, 30.7% of men and 16.8% of women had a coronary artery calcium score of 100 or greater, with male sex, increasing age, diabetes, and smoking identified as key predictors.

Authors

SDSabine J A M DenissenCACarlijn M. van der AalstMVMarleen Vonder

Discussion

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Overview

May identify high-risk asymptomatic adults for prevention intensification; hypothesis-generating for CAC-guided management.

Study Design

Type

Cross-Sectional (n=12,950)

Randomization

1:1:1

Multicenter

Yes

PICO

P
Population
12,950 asymptomatic high-risk individuals aged 45-74 years from the Netherlands who underwent baseline coronary artery calcium screening in the ROBINSCA trial.
E
Exposure / Comparator
Cardiovascular risk factors
O
Primary Outcome
Prevalence and predictors of coronary artery calcium (CAC) score ≥ 100

Limitations

  • Population is not representative of all ethnic groups due to a homogeneous distribution
  • Possible healthy volunteer effect
  • Exclusion of participants using both cholesterol-lowering and antihypertensive medication may have affected associations
  • Baseline data were obtained using a self-reported questionnaire rather than diagnostic test measures

Cite This Study

Denissen et al. (2020) conducted a cross-sectional in Asymptomatic high cardiovascular risk (n=12,950). Cardiovascular risk factors was evaluated on Prevalence and predictors of coronary artery calcium (CAC) score ≥ 100. In a high-risk asymptomatic population, 30.7% of men and 16.8% of women had a coronary artery calcium score of 100 or greater, with male sex, increasing age, diabetes, and smoking identified as key predictors.

synapsesocial.com/papers/6a9e46b6f76ddda103f9a443https://doi.org/10.1177/2047487320932263
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Screening for cardiovascular disease risk using traditional risk factor assessment or coronary artery calcium scoring: the ROBINSCA trial2020 · 96 citations
  2. 2Risk or Benefit in Screening for Cardiovascular Disease (ROBINSCA): The Rationale and Study Design of a Population-Based Randomized-Controlled Screening Trial for Cardiovascular Disease2019 · 17 citations
  3. 3Prevention of sudden death: the role of coronary artery calcification imaging in preventive cardiology2020
  4. 4Impact of a cardiovascular disease risk screening result on preventive behaviour in asymptomatic participants of the ROBINSCA trial2019 · 38 citations
  5. 5Short-term impact of cardiovascular screening by traditional risk assessment or coronary artery calcium score on health-related quality of life: the ROBINSCA trial2024